![]() Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. General: Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients. Hydrocortisone is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. ![]() Hydrocortisone is generally applied to the affected area as a thin film one or four times a day depending on the severity of the condition. Hydrocortisone is used for topical application in the treatment of various skin disorders: treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, management of refractory lesions of psoriasis, and other deep-seated dermatoses.Īlthough it is considered that Hydrocortisone has fewer side-effects on the skin and is less liable to cause adrenal suppression than the more potent topical corticosteroids, it should be borne in mind, that this property may be considerably modified both by the type of formulation or vehicle used and by the type of esterification present other factors that may also influence the degree of absorption include the site of application, use of an occlusive dressing, the degree of skin damage, and the size of the area to which the preparation is applied.
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